LAK細胞による自己癌細胞障害試験の問題点と臨床的意義

概要

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We evaluated the usefulness of LAK define cytotoxicity against autologous tumor cells in 32 patients with head and neck cancer (H & N) and 10 with gynecological (uterocervical)cancer. LAK cells in 2 patients (10%) with squamous cell carcinoma (SCC) of the H & N demonstrated significant autologous tumor-killing activities on 4 hr <SUP>51</SUP>Cr-release assay. These 2 patients had no evidence of recurrent primary tumor, but died of other diseases. In three cases (33%) of gynecological SCC and all cases (100%) of thyroid cancer significant autologous tumor-killing activities were demonstrated. Thyroid cancer patients had good prognoses except in one case of distant metastasis. These results indicated that the autologous tumor-killing activity of LAK cells may be a good indicator of post-operative prognosis, and that immunological responses to autologous tumor in patients with SCC differ according to the site of tumor burden. However, measuring this cytotoxic activity was difficult due to problems concerning viability of tumor cells and techniques.
耳鼻咽喉科臨床学会の論文