新規イネいもち病殺菌剤トルプロカルブのメラニン生合成経路における作用機構：従来のメラニン生合成阻害剤とは異なる作用点

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概要

• 論文の詳細を見る

• The target site of tolprocarb, a novel systemic fungicide used for controlling rice blast, was investigated. Tolprocarb decolorized the mycelia of Magnaporthe grisea; the decolorization was reversed by adding scytalone or 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN). This result suggested that the target site of tolprocarb was polyketide synthase (PKS), which regulated polyketide synthesis and pentaketide cyclization in melanin biosynthesis. Further, we produced a transgenic Aspergillus oryzae, which possessed the PKS gene of M. grisea, and performed in vitro assays of PKS using membrane fractions from the transgenic A. oryzae. Compared with some conventional melanin biosynthesis inhibitors (cMBIs), tolprocarb only inhibited PKS activity in vitro. These results indicated that tolprocarb's target protein in M. grisea was PKS, which differentiates this fungicide from other cMBIs.

• 日本農薬学会の論文

著者

• 平瀬 寒月

  Agrochemicals Group Functional Chemicals Laboratory R&d Center Mitsui Chemicals Inc.

• 里沢 智美

  Purchasing Division, Mitsui Chemicals, Inc.

• 濱田 崇宏

  Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.

• 麻薙 峰子

  Department of Business Innovation Development, Japan Science and Technology Agency, K's Gobancho

• 安楽城 夏子

  Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.

• 番場 伸一

  Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.

• 東村 紀一

  Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.

• 明瀬 智久

  Agrochemicals Research Center, Mitsui Chemicals Agro, Inc.

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• 新規イネいもち病殺菌剤トルプロカルブのメラニン生合成経路における作用機構：従来のメラニン生合成阻害剤とは異なる作用点

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