Inhibition of Human Enterovirus 71 Replication by Pentacyclic Triterpenes and Their Novel Synthetic Derivatives

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概要

• 論文の詳細を見る

• A large number of bioactive pentacyclic triterpenoids have been shown to have multiple biological activities. This study was conducted to evaluate the inhibitory activities of 6 newly synthesized and novel pentacyclic triterpenoids against enterovirus 71 (EV71). The parent compound, ursolic acid (UA), showed the greatest inhibitory activity against EV71, while oleanolic acid (OA), asiatic acid (AA), and synthetic derivatives of 18-β-glycyrrhetinic acid (GA) and OA also exhibited inhibitory effects, although to lesser extents. The results suggest these compounds show potential for further optimization as antiviral candidates for treatment of EV71 infections.

• 公益社団法人 日本薬学会の論文

著者

• Feng Bin

  Department Of Biotechnology College Of Basic Medical Sciences Dalian Medical University

• Zhang Ying-qiu

  Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences

• Zhao Chun-hui

  School of Life Sciences, Liaoning Normal University

• Xu Jie

  School of Life Sciences, Liaoning Normal University

• Zhao Long-xuan

  Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery

関連論文

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• Optimum Balancing of Shaking Force and Shaking Moment for Spatial RSSR Mechanism Using Genetic Algorithm
• Inhibition of Human Enterovirus 71 Replication by Pentacyclic Triterpenes and Their Novel Synthetic Derivatives

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