The Effects of Implant Surface Characteristics on Surrounding Bone: A Comparative Study of Two Types of Surface Characteristics
スポンサーリンク
概要
- 論文の詳細を見る
The aims of this study were to create experimental implants by coating rough plastic surfaces with a thin layer of titanium, and to use the experimental implants in an animal experiment to investigate whether differences in the surface characteristics of the implant affect the peri-implant bone reaction during the period of osseointegration. Titanium rods of diameter 1.6 mm and length 7 mm were treated by acid etching (AE) or sandblasting followed by acid etching (SA), and replicas were made from plastic. Experimental implants were created by depositing a thin layer of titanium on the plastic replicas by DC-magnetron sputtering, and the surface characteristics of the experimental implants were evaluated. The experimental implants were placed in the tibias of eight-week-old male SD rats. The rats were sacrificed and the implants harvested at 3, 5, 10, 14, 21 and 28 days after implant placement. The samples were examined by optical microscopy and micro-CT to confirm peri-implant new bone growth. Examination of the experimental implants by SEM imaging showed that the different surface conditions (SA and AE) had been faithfully recreated. TEM observation and XPS analysis confirmed that the coating was titanium. The surface roughness of SA and AE was 2.68±0.536 μm and 0.47±0.069 μm, respectively. With AE, the BMD of peri-implant trabecular bone showed that bone mineralization progressed not on the surface of the implant but at sites a small distance away. At day 28 after placement of the implant, when osseointegration was complete, the BMD value in the region near the implant surface was higher in SA than in AE. Furthermore, the BV/TV value was high at an earlier stage in SA than AE. The results showed that the SA surface was better than the AE surface for achieving osseointegration.
- 硬組織再生生物学会の論文
硬組織再生生物学会 | 論文
- BMPの臨床応用の問題点と解決
- ブタ顎関節関節円板、後部結合組織、下顎頭線維層におけるプロテオグリカンの比較検討
- 過酸化水素処理による骨芽細胞様細胞株MC3T3-E1のbone nodule形成への影響 : 石灰化物の結晶学的検索
- BMPを付与した電気化学的表面改質Ti及びHA-G-Ti複合材料の骨形成能
- 骨形成蛋白(BMP)の骨膜代用材としての応用 : ヒト大腿筋膜(SolVent Dehydrated Human Fascia Lata)との併用