Guided Bone Regeneration using Hydroxyapatite-Coated Titanium Fiber Web in Rabbit Mandible: Use of Molecular Precursor Method
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概要
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As a non-degradable material showing excellent biological compatibility and mechanical properties, the titanium fiber web (TW) scaffold has been applied in bone regeneration. It is generally accepted that hydroxyapatite (HA) coating accelerates osteoblast maturation and functional activity on the titanium surface. Recently, a thin HA coating using the molecular precursor method was developed, and sufficient apatite coating was achieved inside TW. The aim of the present study was to evaluate the bone-forming capacity using HA-coated TW (HA-TW) in external augmentation. Sintered titanium fiber mesh was processed into a three-dimensional scaffold structure with a fiber diameter of approximately 20 μm. The external and internal diameters of TW were 8.0 and 3.7 mm, respectively. The molecular precursor solution was made by mixing Ca-EDTA/ amine ethanol solution and metaphosphate salt, and the Ca/P ratio was adjusted to 1.67. After immersing TW in the solution, it was heated at 600 °C for 2 hours. Six rabbits were assigned randomly to receive either HA-TW scaffold or TW on each side of the posterior mandible. The 3-mm-long toroidal titanium scaffolds were fitted into the osseous implant. Both TW- and HA-TW-fixed implants were then placed bilaterally with a transverse orientation. The animals were sacrificed at 12 weeks post-surgery, and new bone formation into the porous structure of TW and HA-TW was observed in non-decalcified sections. The newly formed bone rate in the HA-TW was significantly greater than that in the non-coated group (8.33±1.21 vs. 3.43±0.45 %, respectively). Furthermore, the rate of vertical bone regeneration was also significantly different between HA-TW and TW (63±15 vs. 33±8 %). Since the thin HA coating improved bone formation in externally placed TW, HA-TW is potentially useful for external bone augmentation.
- 硬組織再生生物学会の論文
硬組織再生生物学会 | 論文
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