Distribution of Collagen Type IV α1-6 Chains and MMP in Oral Squamous Cell Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Destruction of basement membrane is an important element in invasion of cancer cells. Type IV collagen, the major component of basement membrane has six distinct α chains. Matrix metalloproteinases(MMPs) are enzymes that can resolve extracellular matrix. In this study, we investigated the localization of six α chains and MMPs in oral squamous cell carcinoma immunohistochemically. In well differentiated squamous cell carcinoma, the localization of α chains showed various patterns. α1 (IV), α2 (IV), α5 (IV) and α6 (IV) chains were stained in almost all basement membranes in the central of cancer. Unique staining with only α5 (IV) and α6 (IV) chains was also observed. In the invasive point of cancer, all α chains mainly became negative, but MMP-2 and MMP-9 were stained strongly. In poorly differentiated squamous cell carcinoma, both α chains and MMPs were not stained. Furthermore, we examined the correlation between distribution of α1 chain and invasive pattern of cancer. We found that the disappearence of α chains correlated closely with invasive activity of cancer.
- 硬組織再生生物学会の論文
硬組織再生生物学会 | 論文
- BMPの臨床応用の問題点と解決
- ブタ顎関節関節円板、後部結合組織、下顎頭線維層におけるプロテオグリカンの比較検討
- 過酸化水素処理による骨芽細胞様細胞株MC3T3-E1のbone nodule形成への影響 : 石灰化物の結晶学的検索
- BMPを付与した電気化学的表面改質Ti及びHA-G-Ti複合材料の骨形成能
- 骨形成蛋白(BMP)の骨膜代用材としての応用 : ヒト大腿筋膜(SolVent Dehydrated Human Fascia Lata)との併用