Angiotensin II Induces Modulation of Calcium Channel Currents in Osteoblasts
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概要
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Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. In addition to its well-established role in circulatory homeostasis, it has been implicated in the process of bone formation. Osteoblasts play a major role in bone formation, employing intracellular Ca2+ as a second messenger to modulate hormonal responses and as a cofactor for mineralization. Voltage-dependent Ca2+ channels (VDCCs) mediate the influx of Ca2+ in response to membrane depolarization. The purpose of this study was to investigate the effects of Ang II on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that Ang II facilitates VDCCs in osteoblasts.
- 東京歯科大学の論文
東京歯科大学 | 論文
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