In vivo and Electron Microscopic Observations of the Responses of the Hepatic Sinusoid to Interleukin-1.
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin-1 (IL-1), which is produced by Kupffer cells and sinusoidal endothelial cells, may play an important role in immunological and microvascular responses to a variety of stimuli in the liver. The responses of the hepatic microvasculature including phagocytic activity of sinusoidal lining cells to IL-1α were examined in C<font size="-2">57</font>Bl/6 mice in vivo and using electron microscopy. One hour after recombinant mouse IL-1α was injected at doses of 80 U, the low dose group, and 800 U, the high dose group, the phagocytic activity of sinusoidal lining cells showed significant differences between the two treated groups and between the two groups and the controls. In the low dose group, the numbers of sinusoids containing blood flow and of leukocytes adhering to the sinusoidal lining remained unchanged, but the former decreased and the latter increased significantly in the high dose group. Ultrastructurally, Kupffer cells that phagocytosed latex particles appeared to have decreased in number while the sinusoidal endothelial cells became phagocytic. A considerable number of leukocytes were seen adhering to the sinusoidal endothelium. These findings demonstrate that IL-1α not only elicited sticking and plugging by leukocytes in sinusoids but also activated phagocytic functions in the hepatic sinusoidal endothelial cells. These endothelial responses are similar to those seen following FV<font size="-2">3</font> virus infection, chronic administration of ethanol, or a combination of cocaine and ethanol, or during extracorporal perfusion, suggesting that IL-1 may participate in these responses.
- 東京歯科大学の論文
東京歯科大学 | 論文
- Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents
- Effects of a mixed infection with Porphyromonas gingivalis and Treponema denticola on abscess formation and immune responses in mice
- Canalicular adenoma arising in the upper lip: review of the pathological findings
- The effect of surface pore size on the differentiation of rat bone marrow cells: morphological observations and expression of bone related protein mRNA
- Acinic cell carcinoma found by recurrence of a mucous cyst in the sublingual gland