Synthesis of Conjugated Oligonucleotide in Solution Phase Using Alkyl-chain-soluble Support
スポンサーリンク
概要
- 論文の詳細を見る
Conjugated oligonucleotides attract interest from various areas such as medicine and nanotechnology. Common synthetic methods, however, rely on heterogeneous coupling strategies that often give low yield. This report describes a new synthetic strategy for conjugated oligonucleotides using an alkyl-chain-soluble support, which allows high-yielding conjugation with various reporter molecules in homogeneous environment. Furthermore, we demonstrated efficient biconjugation due to successive introduction of thiol and amine into one linker.
- 公益社団法人 日本化学会の論文
著者
-
CHIBA Kazuhiro
Laboratory of Bio-organic Chemistry Tokyo University of Agriculture and Technolgy
-
KIM Shokaku
Laboratory of Bio-organic Chemistry Tokyo University of Agriculture and Technolgy
-
Shoji Takao
Laboratory of Bio-Organic Chemistry, Tokyo University of Agriculture and Technology
関連論文
- Enantioselective Total Syntesis of (+)-Isoboonein
- Inhibitory Effect of Acylphloroglucinol Derivatives on the Replication of Vesicular Stomatitis Virus
- Effect of the Oxidation of Free Fatty Acids on the Interfacial Adsorptivity of Lysophosphatidylcholine/Free Fatty Acid/Ovalbumin Complexes
- Stereoselective Synthesis of (±)-7β-Acetoxyvouacapane
- Novel Antioxidants Isolated from Perilla frutescens Britton var. crispa (Thunb.)
- Design, Synthesis and Antiangiogenic Activity of the Vitamin D Binding Protein-Macrophage Activating Factor(DBP-maf)-Derived Synthetic Peptide
- Development of Solution-Phase Peptide Synthesis Protocol toward Automatic Synthesizer by Using Precipitation Method
- One-Pod Solution-Phase Peptide Synthesis Using Less-Polar Platforms
- Development of an Effective Synthesis Method for the Automatic Solution-Phase Peptide Synthesizer
- Development of an Automatic Solution-Phase Peptide Synthesizer
- Phase-Separable Aqueous Amide Solutions as a Thermal History Indicator
- Synthesis of Various Proline Derivatives Using Organic Electrochemical Methods
- A Cycloalkane-based Thermomorphic System for Organocatalytic Cyclopropanation Using Ammonium Ylides
- シクロアルカン-ニトリル熱相溶現象を利用した有機電解反応系の構築
- Construction of Cycloalkane-based Thermomorphic (CBT) Electrolyte Solution Systems and Application for Anodic Conversion of a Furan Derivative
- Anodic Carbon-Carbon Bond Formation in Lithium Perchlorate/Nitromethane Electrolyte Solution
- Cyclic Voltammetric Studies on Anodic Cycloaddition Reactions between Electrogenerated Phenoxonium Cations and Alkenes
- Synthesis of Conjugated Oligonucleotide in Solution Phase Using Alkyl-chain-soluble Support