Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.

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We conducted combination therapy with cyclophosphamide, vincristine, and dacarbazine (CVD) for recurrent malignant pheochromocytoma. A 41-year-old woman with ectopic malignant pheochromocytoma had metastases to the liver and left cervical lymph node 7 months after removal of theprimary lesion. At the beginning of October 1999, she was treated with fhe CVD regimen. After 3 courses of chemotherapy, metastases disappeared and urinary catecholamine decreased to normal levels. Only serum noradrenalin was not normalized by the end of treatment. Nine months later, computed tomography (CT) scans of the cervix andabdomen showed recurrent tumors. The woman was treated with the CVD regimen again, but tumor size and biochemical tumor markers remained unchanged. The CVD regimen was thus effective as a primary treatment for malignant pheochiromocytoma with metastases.
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