Emergence of .BETA.-lactam resistance in Pseudomonas aeruginosa.
スポンサーリンク
概要
- 論文の詳細を見る
The emergence of β-lactam resistant mutants of <I>Pseudomonas aeruginosa</I> S-1278, a clinical isolat susceptible to β-lactams, was investigated in a rat pouch infection model using 4 β-lactam antibiotics: piperacillin (PIPC), tazobactam/piperacillin (TAZ/PIPC), ceftazidime (CAZ), and imipenem (IPM). After intravenous administration of 20 and 100mg/kg of each drug in the rat pouch infection model, the frequency of mutants resistant to PIPC and TAZ/PIPC were <1.0×10<SUP>-5</SUP> to 3.7×10<SUP>-8</SUP>: lower than those of CAZ and IPM (2.4×10<SUP>-5</SUP> to 7.5×10<SUP>-5</SUP>). The frequency of mutants resistant to CAZ increased drastically after 3 administrations, and its frequency (4.7×10<SUP>-2</SUP> to 2.17times;10<SUP>-1</SUP>) was the highest. No significant difference of frequency of resistant mutants was seen among the 4 β-lactam antibiotics <I>in vitro</I>, but CAZ selected resistant mutants in a wider concentration than in other antibiotics. In conclusion, the frequency of mutants resistant to PIPC was comparable to that of TAZ/PIPC, and was lower than for CAZ and IPM in the rat pouch infection model.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
- DISPOSITION OF 7432-8 IN RATS (I)
- CLINICAL STUDIES ON T-1220 IN SURGICAL CASES
- CLINICAL STUDIES OF PIVALOYLOXYMETHYL D-α-AMINOBENZYL-PENICILLINATE HYDROCHLORIDE IN SURGICAL INFECTIONS
- STUDIES ON AC-1370
- Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.