Classification of .BETA.-lactamases by utilizing the enzyme inhibitors.
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概要
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A simple and rapid method for classification of β-lactamases in bacterial cells into classes A, B, C and D was devised by utilizing three β-lactamase-inhibitors clavulanic acid, a carbapenem derivative (J-110, 441) and a monobactam derivative (Syn-2161). On the basis of the combined effects of ampicillin with the inhibitor on the MIC of ampicillin, the enzyme class in the test organisms was estimated. This method was evaluated according to its application in 14 bacterial strains, which consisted of seven gramnegative species. For routine assay, a liquid microdilution method for MIC determination was employed. However, the time required for assay was reduced to one-fifth by employing an ATP-bioluminescens method developed by Hattori N, et al.(Antimicrob. Agents Chemother., 42: 1406-1411, 1998).
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公益社団法人 日本化学療法学会 | 論文
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