Impact of cefozopran on gastrointestinal microflora in gastrointestinal surgery.
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概要
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To assess the influence of perioprative administration of cefozopran on intestinal flora, we analyzed changes in bacterial counts in faeces obtained from 9 patients receiving 3 gram of cefozopran daily for 3 days after gastrectomy. Stool samples were collected before surgery and after 3-day cefozopran administration. No change was seen in total counts of aerobes or <I>Escherichia coli</I>. No significant decrease was seen in total counts of anaerobes. <I>Bifidobacterium</I>, <I>Eubacterium</I>, and <I>Bacteriodes</I> counts did not decreased after administration. No overgrowth was seen in <I>Pseudomonas aeruginosa</I>, <I>Candida</I> spp., <I>Clostridium difficile</I>, or methicillin-resistant <I>Staphylococcus aureus</I>, exept for <I>Enterococcus</I> app. Our results suggest that cefozopran did not disturb the ecological balance in intestinal flora after short-term administration.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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