<I>In Vitro</I> and <I>In Vivo</I> Postantibiotic Effects of Gatifloxacin, a New Quinolone
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<I>In vitro</I> and <I>in vivo</I> postantibiotic effects (PAE) of gatifloxacin (GFLX) were compared with that of ofloxacin.<BR>1. <I>In vitro</I> PAE of GFLX for 4 MIC at 1 hour exposure to <I>Staphylococcus aureus</I> Smith, <I>Streptococcus pneumoniae</I> IID552, <I>Enterococcus faecalis</I> IID682 and <I>Klebsiella pneumoniae</I> BK were 2.1-4.1 hours. <I>In vitro</I> PAE of GFLX against <I>S.aureus</I> and <I>S.pneumoniae</I> was comparable to that of ofloxacin, whereas that of GFLX against <I>E.faecalis</I> and <I>K.pneumoniae</I> BK was more than that of ofloxacin.<BR>2. <I>In vivo</I> PAE of GFLX and ofloxacin with a dose of 4mg/kg against <I>K.pneumoniae</I> thigh infection in neutropenic mice were 4.5 and 1.2 hours, respectively.<BR>3. Effective regrowth times (ERT) of GFLX with doses of 4 and 8 mg/kg against <I>K.pneumoniae</I> BK were more than 12 hours and more than 16 hours, respectively. That of ofloxacin with a dose of 4mg/kg was 6.6 hours.
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