Effect of combination therapy of fosfomycin and other antimicrobial agents against Pseudomonas aeruginosa strains isolated from sputa.
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We studied the combined effects of fosfomycin (FOM) with other antimicrobial agents, such as sulbactam/cefoperazone (SBT/CPZ), ceftazidime (CAZ), aztreonam (AZT), ofloxacin (OFLX), panipenem/betamipron (PAPM/BP), imipenem/cilastatin (IPM/CS), dibekacin (DKB) and piperacillin (PIPC), <I>in vitro</I> against 20 strains of <I>Pseudomonas aeruginosa</I> isolated from sputa. Combined effects were observed in all agents tested in this study. The mean fractional inhibitory concentration indexes were 0.38 in SBT/CPZ, 0.42 in CAZ, 0.46 in AZT, 0.56 in OFLX, 0.64 in PAPM/BP, 0.65 in PIPC, 0.66 in IPM/CS and 0.77 in DKB. In combination therapy with FOM, the cumulative percentage of MIC under serum concentrations of agents at three hours after intravenous administration were 100% in SBT/CPZ, 95% in CAZ, 95% in AZT, 90% in DKB, 85% in PAPM/BP, 85% in IPM/CS, 85% in OFLX and 80% in PIPC. These results suggests that the most effective combination therapy was that of FOM with SBT/CPZ.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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