Impact on intestinal flora after administration of flomoxef in gastroenterological surgery.
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To determine the impact of postoperatively administered flomoxef on normal intestinal flora, we studied in patients who underwent distal gastrectomy. Flomoxef was administered to 7 patients for 4 days. Feces was examined for bacteria before surgery, day 4 of therapy and 1 week after completion of therapy. No change in the anaerobic bacterial count was found after antibiotic administration. Investigation of the major genera of colonic anaerobes revealed that the numbers of <I>Bacteroides</I> spp. were maintained during flomoxef administration. However the number of <I>Bifidobacterium, Veillonella</I> and <I>Clostridium</I> spp. decreased significantly. With regard to the aerobic bacterial count, little change was observed. The numbers of <I>Eecherichia coli</I> were maintained. No significant microbial substitution was detected. Although the number of <I>Enterococcus</I> spp. tended to increase, there were no signigicant changes in the numbers of <I>Staphylococcus</I> spp. and <I>Candida</I> spp. The present study showed that although ecological balance showed a slight change, the function of intestinal flora is mostly maintained by shortterm (4 days) postoperative abministration of flomoxef.
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