Effect of concomitant use of a aluminum hydroxide/magnesium hydroxide combination with antibacterial drugs against Helicobacter pylori in vitro.
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Maalox<SUP>®</SUP> dry suspension granule (MLX-G), a granular preparation of Maalox<SUP>®</SUP>, an antacid widely used all over the world, is suspended in water immediately before use. In this study, we investigated the effect of concomitant use of MLX-G and antibacterial drugs on clinical isolates of Helicobacter pylori under the acidic conditions. The result showed that the MIC of clarithromycin (CAM) tended to be decreased by MLX-G. This tendency was especially remarkable for CAM-resistant organisms, and the MIC of OTR 10, one of the strains, decreased from 32μg/ml to 0.5μg/ml. MBC of amoxicillin (AMPC) was also decreased by MLX-G. The enhanced effect of antibacterial drugs observed in this experiment was considered to be mainly attributable to the increase in pH due to the addition of MLX-G. However, the enhanced effect when used concomitantly use with AMPC appeared to be related to other factors as well.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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