Effect of erythromycin on hypothalamo-pituitary-adrenal system.

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Erythromycin has now been thoroughly demonstrated to have an excellent therapeutic effect in the patients with chronic lower respiratory infection. However, the mechanism of action of the drug remains controversial. We studied the effect of macrolides on endogenous corticoids in mice. Erythromycin (100mg/kg, i. p.) significantly increased serum corticoid levels, but josamycin (100 mg/kg, i. p.) had little effect on them. The increase in the corticoid levels was completely suppressed by pretreatment with dexamethasone. These findings suggest that erythromycin increases corticoid levels through activation of the hypothalamo-pituitary-adrenal system. This increase in corticoid levels may be one of the mechanisms of the clinical efficacy of erythromycin in chronic lower respiratory infections.
公益社団法人日本化学療法学会の論文