<I>In vitro</I> and <I>in vivo</I>antimicrobial activity of azithromycin, a new macrolide antibiotic
スポンサーリンク
概要
- 論文の詳細を見る
The <I>in vitro</I> and <I>in vivo</I> activities of azithromycin (AZM) were compared with those of erythromycin (EM), clarithromycin (CAM), josamycin (TM), midecamycin acetate (MDM), rokitamycin and cefaclor. MICs of AZM for <I>Staphylococcus aureus, Streptococcus pyogenes</I> and <I>Streptococcus pneumoniae</I> were generally two to eight-fold higher than those of EM and CAM. AZM was two to eight-fold more active than EM and CAM against <I>Neisseria gonorrhoeae, Moraxella catarrhalis</I> and <I>Haemophilus influenzae</I>.<BR>Neither growth media nor inoculum size had any marked effect on the <I>in vitro</I> potency of AZM or EM. The presence of horse serum enhanced the activity of both AZM and EM. An alkaline medium decreased the MIC values of AZM and EM, while an acidic medium increased MIC values.<BR>AZM showed clear bactericidal activities against <I>S. aureus</I> at two-fold its MIC and against <I>H. influenzae</I> at its MIC. MBC<SUB>90</SUB> of AZM for <I>S. aureus</I> and <I>S. pyogenes</I> were six and eight dilutions higher than its MIC<SUB>90</SUB>, when incubated with antibiotics for 24h. However, when the incubation time was increased to 48 or 72h, MBC<SUB>90</SUB> of AZM decreased and were equal to the MIC<SUB>90</SUB>.<BR>The rates of in vitro emergence of resistance to AZM were similar to those of EM and CAM in <I>S. aureus, S. pyogenes</I> and <I>H. influenzae</I>.<BR>Therapeutic activities of AZM against systemic murine infections with <I>S. aureus, S. pyogenes</I> and <I>S. pneumoniae</I> were greater than those of EM and MDM, even though EM and MDM exhibited greater <I>in vitro</I> potencies. In a murine model of respiratory infection with <I>H. influenzae</I>, AZM significantly reduced the recoverable pathogen counts as compared with CAM.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
- DISPOSITION OF 7432-8 IN RATS (I)
- CLINICAL STUDIES ON T-1220 IN SURGICAL CASES
- CLINICAL STUDIES OF PIVALOYLOXYMETHYL D-α-AMINOBENZYL-PENICILLINATE HYDROCHLORIDE IN SURGICAL INFECTIONS
- STUDIES ON AC-1370
- Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.