New oral quinolone, balofloxacin, in the treatment of patients with surgical infection
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As part of a two-part investigation, a pharmacokinetic study was performed with four patients during bile drainage as the subjects.<BR>Two tablets (200 mg) of balofloxacin (BLFX), a new oral quinolone, was administered and serial samples of blood and bile were taken. The peak levels of BLFX in the plasma were 1.01-1.54μg/ml at 4-6h after the start of administration, and the peak levels in the bile were 4.61-23.13μg/ml at 2-6h.<BR>In the second part of the study, 51 patients were treated.<BR>Clinical efficacy was excellent in 18 infections, good in 24 infections, fair in 6 infections, and poor in 3 infections with an efficacy of 82%.<BR>The bacteriological response of 50 strains of 21 bacterial species isolated was evaluated. Forty-seven strains were eradicated and three strains persisted, with an eradication rate of 94%. The bacteriological response of the host was evaluated in 33 infections.<BR>Bacteria were eradicated in 29 infections, decreased in one, were replaced in two and persisted in one with an eradication rate of 94%.<BR>The MIC was calculated for 54 strains isolated, and 28 strains of them required the MIC of 0.39μg/ml or more to be inhibited. The bacteriological response of 42 strains of MIC were calculated was evaluated. All 22 strains, which required the MIC of 0.20μg/ml or less to be inhibited, were eradicated.<BR>Two patient of diarrhea and one patient of skin eruption were reported. No abnormal changes in laboratory test results which might be caused by this drug, was found. BLFX seemed to be effective for skin and soft tissue infections and bile duct infections.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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