In vitro antibacterial activity of pazufloxacin against bacteria adhering to solid phase

概要

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It is well known that bacteria that form a biofilm are strongly resistant to many antimicrobial agents. Prior to biofilm formation, i.e., during adherance to the solid phase, bacteria also show resistance to the bactericidal activity of antimicrobial agents. In evaluating antimicrobial agents, their antibacterial activity against adherent bacteria should also be determined. The antibacterial activity of a newly developed quinolone antimicrobial agent, pazufloxacin (PZFX), against bacteria adhering to the solid phase was determined and compared with that of ofloxacin (OFLX), ciprofloxacin (CPFX) and tosufloxacin (TFLX). PZFX showed a significantly low MIC for adherent Staphylococcus aureus (MICAD) and MBC for adherent S. aureus (MICAD). Against Staphylococcus epidermidis, the MICAD and MICAD of PZFX were equal or superior to those of CPFX and OFLX, whereas, inferior to those of TFLX. PZFX showed lower MICAD for Pseudomonas aeruginosa than CPFX and OFLX, whereas the MICAD of PZFX was inferior to that of CPFX. Against Escherichia coli, the MICAD and MICAD of PZFX were equal to those of TFLX, but the MICAD of PZFX was superior to that of CPFX and OFLX. These results suggest that PZFX is an effective quinolone preparation for adherent bacteria.
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