Basic and clinical studies of biapenem
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概要
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We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic.<BR>1) Antibacterial activity:<BR>The MIC of BIPM against 319 clinical isolates of 9 species were compared with those of imipenem (IPM), piperacillin (PIPC), ceftazidime (CAZ).<BR>59 strains of methicillin-resistant <I>Staphylococcus arureus</I> (MRSA) against BIPM showed susceptible distribution of 0.0625-128μg/ml (with the peak of 4μg/ml), 67 strains of methicillin-sensitive Staphylococcus arureus (MSSA) 0.0625-0.5μg/ml (0.125μg/ml), and 22 strains of Enterococcus faecalis 0.0625-32μg/ml (1μg/ml), exhibiting one or two fold less activity of BIPM than that of IPM.<BR>24 strains of Staphylococcus epidermidis showed a distribution of 0.0625-64μg/ml with the peak of 0.0625μg/ml.<BR>63 strains of <I>Pseudomonas aeruginosa</I> showed a distribution of 0.0625-16μg/ml (with the peak of 1μg/ml), 16 strains of <I>Serratia marcescens</I> 0.0625-4μg/ml (1μg/ml), 24 strains of <I>Klebsiella pneumoniae</I> 0.0625-0.5μg/ml (0.0625μg/ml), 33 strains of <I>E. coli</I> 0.0625 yernl (0.0625μg/ml), and 11 strains of <I>Acinetobacter calcoaceticus</I> 0.0625-0.25μg/ml (0.125μg/ml), exhibiting that the antibacterial activity of BIPM was superior to IPM.<BR>2) Clinical study:<BR>BIPM was administered to 7 patients (bacterial pneumonia in 5, pneumoniosis +infection in 1, and chronic bronchitis in 1) at a dose of 0.6g per day for 14 days.<BR>The clinical efficacy was excellept in 6 cases and unknown in 1 case.<BR>Adverse reaction was observed with rash in 1 case.<BR>Abnormal laboratory finding were observed with eosinophilia in 2 cases.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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