Antibacterial activity and clinical studies on FK037 in complicated urinary tract infections
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概要
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We investigated the antibacterial activities and the clinical effects of FK037.<BR>The MIC<SUB>90</SUB> of FK037 against gram-positive cocci was 2.0 μg/ml for methicillin-sensitive <I>Staphylococcus aureus</I> (MSSA) and 32 μg/ml for methicillin-resistant <I>S.aureus</I> (MRSA). In comparison with other antibiotics, that of FK037 for MSSA was higher than those of flomoxef (FMOX) and imipenem (IPM), but antibacterial activity of FK037 for MRSA was superior to other antibiotics.<BR>Against gram-negative rods, the MIC<SUB>90</SUB> of FK037 was 0.063μg/ml for <I>Escherichia coli</I>, 0.25 μg/ml for <I>Klebsiella pneumoniae</I>, 0.25 μg/ml for indole-positive <I>Proteus</I> spp., and activity of FK037 was 1-5 grade superior to other antibiotics.<BR>Against <I>Pseudomonas aeruginosa</I>, the MIC<SUB>90</SUB> of FK037 was higher than that of IPM, equal to CAZ and 5 grades lower than that of FMOX.<BR>In clinical study, FK037 was administered to 9 patients with complicated urinary tract infections, and the clinical effects and side effects were investigated. FK037 was administered at doses of 0.25, 0.5, 1.0 g, twice a day for 5 days.<BR>The general clinical effects were evaluated according to the criteria proposed by the Japanese UTI Committee, and was excellent in 3 patients and good in 4.<BR>Ten strains of causative organisms were eliminated, and no isolates appeared after treatment were observed.<BR>No side effects were observed, and in laboratory findings, a slight elevation of GOT and an elevation of GOT, GPT were seen each 1 patient.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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