Basic and clinical studies on tazobactam/piperacillin in internal medicine
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Fundamental and clinical investigations on tazobactam/piperacillin (TAZ/PIPC), a new injectable antibiotic, were carried out.<BR>The MICs (λg/ml) of TAZ/PIPC and PIPC to highly resistant <I>Staphylococcus aureus</I> (35 strains, MICs to MPIPC were≥32 λg/ml) were 8->128 and 16->128, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of TAZ/PIPC to highly resistant <I>S. aureus</I> were 32 and 128, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of PIPC to highly resistant <I>S. aureus</I> were 64 and>128, respectively.<BR>The MICs (λg/ml) of TAZ/PIPC and PIPC to moderately resistant <I>S. aureus</I> (44 strains, MICs to MPIPC were 0.25-2 λg/ml) were 0.5-4 and 0.5-32, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of TAZ/PIPC to moderately resistant <I>S. aureus</I> were 2 and 4, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of PIPC to moderately resistant <I>S. aureus</I> were 4 and 16, respectively.<BR>The MICs (λg/ml) of TAZ/PIPC and PIPC to <I>Klebsiella pneumoniae</I> were 0.2-25 and 0.2->100, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of TAZ/PIPC to <I>K. pneumoniae</I> were 3.13 and 6.25, respectively.<BR>The MIC<SUB>50</SUB> and MIC<SUB>90</SUB> (λg/ml) of PIPC to <I>K. pneumoniae</I> were 3.13 and 50, respectively.<BR>TAZ/PIPC was administered to 17 patients (pneumonia 4 cases, chronic bronchitis 4, bronchial asthma with infection 3, pulmonary emphysema with infection 2, pulmonary fibrosis with infection 1, acute cystitis 1, acute cholecystitis 1 and sarcoidosis 1).<BR>Clinical efficacy in the 17 patients was excellent in 2, good in 9, fair in 1, poor in 2 and unevaluable in 3 cases.<BR>The overall efficacy rate was 78.6%.<BR>The efficacy rate in the 12 patients with RTI was 83.3%.<BR>An adverse effect, rash, was observed in one case.<BR>Abnormal laboratory findings were slightly elevated GOT and GPT, serum-K and serumcreatinine in 1 case each.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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