Antibacterial activities and clinical efficacy of cefozopran in genitourinary tract infections
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概要
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We studied the antibacterial activities of a new cephem antibiotic, cefozopran (CZOP), and its clinical efficacy in genitourinary tract infection.<BR>1. The antibacterial activities of CZOP against reference strains and various isolates from urinary tract infections was compared with those of the controls, ceftazidime (CAZ), cefuzonam (CZON) and ceftizoxime (CZX). CZOP showed strong antibacterial activities against both gram-positive and gram-negative bacteria of the standard strains.<BR>As for the clinical isolates, antibacterial activities of CZOP was superior to the controls against most bacterial species except for<I>Serratia marcescens, </I>especially for<I>Citrobacter freundii, Enterobacter cloacae</I>and <I>Pseudomonas aeruginosa.</I><BR>2. Twenty-six patients with complicated urinary tract infection and one patient with acute prostatitis were treated with CZOP at a dose of 0.5g, 1g, or 2g b. i. d. for 5-11 days. According to the criteria proposed by the Japanese UTI Committee, 23 patients were evaluated and the overall efficacy rate was 74%. One patient with acute prostatitis was assessed as excellent by Dr's evaluation.<BR>As for adverse reactions, diarrhea was observed in one patient. Eosinophilia was noticed in 2 patients and elevation of serum enzymes (ALP, GOT, GPT and γ-GTP) in 5 patients. However, these reactions and changes were mild and tansient. We conclude that CZOP is useful in the treatment of genitourinary tract infections.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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