Effect of parenteral teicoplanin on human fecal flora

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The effect of 7-day administration of teicoplanin (TEIC), a novel glycopeptide, on human fecal flora was studied. Intravenous drip infusion at a dose of 4mg/kg of TEIC was given once a day to 5 healthy adult males. One of the 5 cases was excluded from the evaluation because TEIC was given for only 5 days (abnormal laboratory findings for liver function were recorded on day 5). Little change in anaerobic and aerobic fecal flora were observed on the genus and group level; most changes in the bacterial number were 2 log or less. Species of the Bacteroides fragilis group, Enterobacteriaceae and Enterococcus spp. were changed little by the administration of TEIC. No differences in susceptibility to TEIC were noted in fecal strains isolated before, during, and after TEIC administration. These results suggest that TEIC had little effect on human intestinal flora.
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