Activity of antibiotics and disinfectants against methicillin-resistant Staphylococcus aureus(MRSA). Difference in sensitivity at three hospitals.:difference in sensitivity at three hospitals

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The activity of 12 antibiotics and 5 disinfectants against 80 strains of methicillin-resistant <I>Staphylococcus aureus</I> (MRSA) isolated from 3 hospitals in 1988 (29 strains) and in 1991 (51 strains) was assessed. Vancomycin (VCM) and arbekacin (ABK) were the most effective of the test antibiotics, and benzalkonium chloride (BAC) and povidone-iodine (PVP-I) were effective as disinfectants gainst the MRSA tested. The coagulase type of the test MRSA strains was mainly type II. Strains coded 6736142 by the API Staph system, were all highly methicillin-resistant <I>S.aureus</I> (high MRSA) (≥100μg/ml). Based on the results of the range of MIC values, ABK, doxycycline (DOXY), minocycline (MINO), VCM and imipenem/cylastatin (IPM/CS) were effective against MRSA strains in 1988, while in 1991 ABK and VCM were effective. Among the above-mentioned antibiotics, in 1991 MRSA was more resistant to MINO, IPM/CS and OFLX than the MRSA in 1988 (p <0.01). Among the disinfectants tested, 0.1% BAC and 0.1% PVP-I were effective against MRSA strains. These results suggest that ABK and VCM are effective in the treatment of MRSA infections and that the use of 0.1% BAC or 0.1% PVP-I solution is suitable to control MRSA infection in these 3 hospitals.
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