<I>IN VITRO</I> ANTIBACTERIAL ACTIVITY AND, β-LACTAMASE STABILITY OF CEFCLIDIN, A NEW PARENTERAL CEPHALOSPORIN
スポンサーリンク
概要
- 論文の詳細を見る
Cefclidin (CFCL) is a new parenteral cephalosporin with a broad antibacterial spectrum and potent antipseudomonal activity. CFCL was 8 to 16 times more active than ceftazidime (CAZ) and cefsulodin against <I>Pseudomonas aeruginosa</I> (MIC<SUB>90</SUB>, 3.13μg/ml). The activity of CFCL against most species of the Enterobacteriaceae family was roughly comparable to those of CAZ and cefmenoxime (CMX) and exceeded that of cefotiam. The activities of CFCL against <I>Citrobacter freundii</I> (MIC<SUB>90</SUB>, 0.78μg/ml), Enterobacter cloacae (MIC<SUB>90</SUB>, 3.13μg/ml), and Enterobacter aerogenes (MIC<SUB>90</SUB>, 0.2μg/ml) were 16 to 256 times greater than those of CAZ and CMX. The activities of CFCL against Gram-positive cocci and anaerobes were comparable to those of CAZ, but CFCL was less active against those types of organisms than CMX. CFCL showed potent antibacterial activity against β-lactamase-producing strains of Enterobacteriaceae and <I>Pseudomonas</I> spp. Its activity was little affected by the levels of β-lactamase production, compared with the other compounds. CFCL was highly stable to hydrolysis by various β-lactamases, except for R plasmid-mediated type II (OXA 1) penicillinase. The susceptiblity profile of CFCL to β-lactamase was almost the same as that of CAZ, but CFCL was more stable than CMX. CFCL also showed an extremely low affinity for β-lactamases from strains of <I>E. cloacae, C. freundii</I>, and <I>P. aeruginosa</I>, as compared with CAZ and CMX. The ability of CFCL to induce β-lactamase was about equal to that of CAZ. CFCL showed high affinities for PBP 3 of <I>E. coli</I> and <I>P. aeruginosa</I>. CFCL caused filamentation at its lowest effective concentrations, as reflected by the affinities of CFCL for PBP 3.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
- DISPOSITION OF 7432-8 IN RATS (I)
- CLINICAL STUDIES ON T-1220 IN SURGICAL CASES
- CLINICAL STUDIES OF PIVALOYLOXYMETHYL D-α-AMINOBENZYL-PENICILLINATE HYDROCHLORIDE IN SURGICAL INFECTIONS
- STUDIES ON AC-1370
- Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.