PHARMACOLOGICAL EFFECTS OF CEFCLIDIN ON GASTROINTESTINAL TRACT, SECRETORY FUNCTION AND RENAL FUNCTION
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概要
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An examination of some general pharmacological effects of cefclidin (CFCL) and (CEZ) cefazolin had been made. A range of standard pharmacological tests were used to investigate effects on the gastrointerstinal tract, secretory function and renal function.<BR>Local anaesthetic activity was also evaluated.<BR>Some increase in the activity of gastrointestinal smooth muscle was observed following both CFCL and CEZ but there was no evidence of an effect on gastrointestinal conduction speed. Secretory function was not affected by CFCL, however, changes in gastric secretion, bile secretion and pancreatic output were observed after CEZ.<BR>The highest does of CFCL caused an increase in urine volume and Na<SUP>+</SUP>, K<SUP>+</SUP>, and Cl<SUP>-</SUP> excretion in rats, Whilst an increase in Nat was seen after CEZ no notable change in urine output was recorded. Glomerular filtration rates were not affected.<BR>CFCL and CEZ were devoid of local anaesthetic activity.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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