<I>IN VITRO</I> ACTIVITY OF MEROPENEM AGAINST CLINICAL ISOLATES AND <I>IN VITRO</I> PHARMACOKINETIC MODEL
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概要
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The antibacterial activity of meropenem (MEPM), a newly developed carbapenem, against clinical isolates of <I>Pseudomonas aeruginosa, Staphylococcus aureus</I> and enterococci, was evaluated by MIC and the in vitro pharmacokinetic model. The MICs of MEPM against <I>P. aeruginosa</I> were lower than those of imipenem (IPM) and ceftazidime (CAZ). Evaluation of antipseudomonal activity of MEPM performed by the <I>in vitro</I> pharmacokinetic model showed larger bactericidal activity and a longer post-antibiotic effect than CAZ. The MICs of MEPM against <I>S. aureus</I> and <I>Enterococcus faecalis</I> were slightly higher than those of IPM.
- 公益社団法人 日本化学療法学会の論文
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