EFFICACY OF MEROPENEM AGAINST EXPERIMENTAL RESPIRATORY TRACT INFECTION AND INTRA-RENAL INFECTION IN GUINEA PIGS

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The in vivo efficacies of meropenem (MEPM), a new parenteral carbapenem, against experimental respiratory tract infection and intra-renal infection in guinea pigs were compared with those of imipenem/cilastatin (IPM/CS) and ceftazidime (CAZ). MEPM was as effective as IPM/CS against pneumonia with 2 strains of Pseudomonas aeruginosa at a dose of 5 mg/kg, and was significantly more effective against one strain and equally effective against the other strain, compared with CAZ. In neutropenic guinea pigs, MEPM was as effective as IPM/CS and was significantly more effective than CAZ at a dose of 5mg/kg against pseudomonal pneumonia. MEPM also showed excellent efficacy against intra-renal infection with P. aeruginosa, Escherichia coli, Proteus mirabilis and Citrobacter freundii at doses of 1 or 5 mg/kg. Against P. aeruginosa, the activity of MEPM was significantly superior to that of IPM/CS and equal to or superior to that of CAZ. Against E. coli, all three drugs were equally effective. Against P. mirabilis, CAZ was the most effective, and MEPM was superior to IPM/CS. Against C. freundii, MEPM was the most effective, and IPM/CS was superior to CAZ.
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