EFFECTS OF CEFDINIR, AN ORAL CEPHEM, IN ACUTE RESPIRATORY TRACT INFECTION
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We investigated the efficacy and safety of cefdinir (CFDN), a new oral cephem, by administering it to 18 patients with acute respiratory tract infection.<BR>The subjects were 11 males and 7 females ranging in age from 31 to 80 years. The drug (100 mg) was given orally in one capsule three times a day after each meal for 4 to 14 days consecutively.<BR>The overall efficacy of CFDN was good in 10, fair in 2 and poor in 1 of the 13 patients with bronchitis, good in all the 3 patients with bronchopneumonia, and excellent in I and fair in 1 of the 2 patients with pneumonia. The efficacy rate was 77.8%.<BR>Bacteriologically, causative organisms from the 12 patients were identified before the beginning of the study. <I>Haemophilus parainfluenzae</I> was eradicated in 4 and persisted in 1 of 5 strains.<BR><I>Haemophilus parahaemolyticus</I> was eradicated in 3 and replaced in 1 of 4 strains. <I>Klebsiella pneumoniae</I>persisted in 1 and was replaced in 1 of 2 strains. Two strains of <I>Streptococcus pneumoniae</I> and one each of <I>Klebsiella oxytoca, Enterobacter cloacae and Enterobacter agglomerans</I> were eradicated. The eradication rate for all the organisms was 89.5%.<BR>No subjective or objective side effects were noted in any of the patients. A slight increase in GOT and GPT was observed in only one patient, but the values returned to normal after the end of the study.<BR>We consider CFDN to be useful in the treatment of acute respiratory tract infection.
- 公益社団法人 日本化学療法学会の論文
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