EXPERIMENTAL AND CLINICAL STUDIES ON 7432-S IN THE FIELD OF UROLOGY
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概要
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We performed experimental and clinical studies on 7432-S, a new cephem antibiotic for oral use.<BR>1) 7432-S had potent antibacterial activity compared with cephalexin (CEX) and cefaclor (CCL) against <I>Escherichia coli, Klebsiella pneurnoniae, Proteu mirabilis</I> and other Gram-negative bacilli.<BR>7432-S was less active, however, than CEX and CCL against Gram-positive cocci.<BR>2) 7432-S was administered orally to healthy volunteers. The drug was given in a single dose of 100 mg with food.<BR>A maximal mean blood level of 4.20 μg/ml was achieved 2 h after administration and a maximal urine level was detected 2-4 h after administration.<BR>The recovery rate in urine after 10 h was 48.3%.<BR>3) Sixteen patients with complicated urinary tract infection were evaluated by the criteria of the Japanese UTI Committee.<BR>The results were excellent in 6 cases and moderate in 2, and the overall clinical efficacy rate was 50%.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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