CEFOTIAM HEXETIL, A NEW ORAL ANTIBIOTIC, IN UROGENITAL INFECTIONS
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概要
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The following findings were obtained for a new oral cephalosporin derivative, cefotiam hexetil (CTM-HE).<BR>1. Diffusion into human prostatic fluid<BR>The concentration of cefotiam (CTM) in the prostatic fluid at 1 hour after administration of 200mg of CTM-HE was 0.05 μg/ml in 2, and less than 0.05 μg/ml in another 2 human subjects. The mean drug concentration in the blood was 3.3 μg/ml (n=4).<BR>2. Clinical study<BR>(1) Acute uncomplicated cystitis (AUC): 22 female patients were given 300 mg daily of CTM-HE for 3 to 8 days. The response, after 3 days, was evaluated according to the Japanese UTI Committee's criteria, and was excellent in 18 patients and moderate in 4, with a response rate of 100%.<BR>(2) Chronic complicated urinary tract infection (CC-UTI): 13 patients were given 600 mg daily of CTM-HE for 5 to 14 days. The response, after 5 days, was evaluated according to the Japanese UTI Committee's criteria, and was excellent in 4 patients, moderate in 6 and poor in 3, with a response rate of 76.9%. A bacteriological study revealed an eradication rate of 15/18 pathogens, or 83.3%.<BR>(3) Urethrogenital infection: patients with urethrogenital infection were given 600 mg daily of CTM-HE for 5 to 12 days. The response was excellent in 1 patient with gonorrhea. Of 4 cases of bacterial prostatitis, the response was good in 2 caused by <I>Escherichia coli</I>, and fair in 2 caused by Gram-positive cocci.<BR>3. Safety<BR>Neither subjective or objective adverse reactions nor abnormal changes in laboratory findings were observed in any patients.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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