RU 28965 IN RESPIRATORY INFECTIONS: SPUTUM AND BLOOD LEVELS AFTER SINGLE ADMINISTRATION

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The authors investigated the sputum and blood levels of RU 28965 (150 mg) after a single oral administration in patients with respiratory infection. The results revealed that although individual differences were great, in all cases maximum blood level was attained 1 h after administration, and a high blood level, such as 10μg/ml, was maintained over 6h. The sputum level rose to 0.5-0.7μg/ml in 6h, and in some cases remained at 0, 5-0.6μg/ml for even 12 h, suggesting good intestinal absorption of the drug. This was reflected in its extremely good transport to sputum. In patients re-tested' after one month, transport to the sputum was still extremely good. The results of a phase II clinical trial (150 mg×2, average 14 days) in 6 patients were almost good, with no side-effects. Recently infections.where no pathogens in sputum can be detected-including atypical pneumonia, chlamydial and legionella infections-have increased. RU 28965 has few side-effects and good intestinal absorption. In this respect, RU 28965 is a promising drug for the treatment of outpatients.
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