CLINICAL AND LABORAORY STUDIES ON CS-807 IN CUTANEOUS BACTERIAL INFECTION

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CS-807, a new cephalosporin, antibiotic was studied clinically and in the laboratory in bacterial infections in dermatological field.<BR>In a clinical study, CS-807 was administered orally to 19 adult patients with various bacterial dermatoses; folliculitis (5), furunculosis (1), whitlow (2), impetigo contagiosa (1), erysipelas (1), acne conglobata (2), infectious atheroma (5), abscess (1 case which dropped out), and secondary infection in a benign tumor (1). Clinical results were: recovery in 13, significant improvement in 3, slight improvement in 1, no change in 1 and drop out in 1. The overall efficacy rate was 88.9%. Poor appetite was complained by two patients, but this was not severe.<BR><I>S. aureus, S. epidermidis, P. acnes, Micrococcus sp., S. simulans, S. hominis, S. pyogenes, K. oxytoca, E. aerogenes, S. milleri, P. prevotii, P. mirabilis and Citrobacter diversus</I> were isolated from clinical specimens. Minimum inhibitory concentrations of CS-807, CEX, CCL, CDX and AMPC against these bacterium were measured. CS-807 proved to be similar or superior to the other drugs against isolated organisms.
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