Studies on the pathogenicity of Enterococcus faecalis - Experimental ascending pyelonephritis in non-treated and diabetic mice.:E XPERIMENTAL ASCENDING PYELONEPHRITIS IN NON-TREATED AND DIABETIC MICE
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We experimentally investigated the pathogenicity of clinically isolated <I>Enterococcus faecalis</I> (<I>E. faecalis</I>) in urinary tract of non-treated and diabetic mice. The results are summarized as follows.<BR>(1) <I>In vitro, </I> new pyridonecarbonic acids (CPFX, OFLX, ENX and NFLX) were most effective against 23 clinically isolated strains of <I>E. faecalis, </I> followed by ST, MINO, ABPC and IPM/CS. Most of the isolates showed high resistance to cephems.<BR>(2) In non-treated mice, ascending pyelonephritis occurred with 9 of 11 <I>E. faecalis</I> strains tested. These strains showed similar pathogenicity (ID<SUB>50</SUB>) compared with four standard Gram-negative species.<BR>(3) In streptozotocin-induced diabetic mice, ascending pyelonephritis occurred with 5 of 5 <I>E. faecalis</I> strains tested and values of ID<SUB>50</SUB> were 1/1.3-1/477 of those in non-treated mice.<BR>(4) As to drug efficacy against experimental ascending pyelonephritis in non-treated mice, CPFX was most effective, followed by OFLX, MINO and ENX.<BR>(5) Against experimental ascending pyelonephritis in streptozotocin-induced diabetic mice, ABPC was most effective, followed by CPFX, MINO and ENX; a longer administration period was necessary to eradicate <I>E. faecalis</I> than in non-treated mice.
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