6315-S (FLOMOXEF), A NEW OXACEPHEM ANTIBIOTIC: STABILITY AGAINST β-LACTAMASES AND AFFINITIES FOR PENICILLIN-BINDING PROTEINS OF <I>ESCHERICHIA COLI</I> AND <I>STAPHYLOCOCCUS AUREUS</I>
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A new oxacephem antibiotic, 6315-S (flomoxef), was stable against penicillinases of both <I>Staphylococcus aureus</I> and Gram-negative bacteria and cephalosporinase of <I>Proteus vulgaris</I>, while it was hydrolyzed by cephalosporinases of other Gram-negative bacteria, though the hydrolysis rates were low.<BR>6315-S bound to the PBP's-la, -1b, -3, -4.-5 and-6 of <I>E. coli</I> K12. It showed high affinity especially for PBP's-1 a and-3. In this respect it was comparable to latamoxef (LMOX), and both antibiotics had similar antibacterial activity against <I>E. coli</I>.<BR>6315-S and cefazolin (CEZ) showed similar affinity for PBP's-2 and -3 of S. aureus ATCC 25923 and both antibiotics had the same MIC. In addition, 6315-S showed high affinity for PBP-4 while CEZ did not. On the other hand, the affinity of 6315-S for PBP-3 was about ten times higher than that of LMOX and cefotaxime (CTX) and about three times higher for PBP-2 than that of LMOX. This might relate to the anti-staphylococcal activity of 6315-S which is four and sixteen times stronger than that of CTX and LMOX, respectively.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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