精子形成能のみられたゴナドトロピン単独欠損症:間脳・下垂体・性腺系のホルモン分泌動態について
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We measured serum and prostate concentrations of cefoperazone (CPZ) following its intravenous administration to 53 patients with benign prostatic hyperplasia.<BR>High concentrations of CPZ were sustained in serum. The drug's biological half-life <I>T</I><SUB>1/2β</SUB>was 133 min.<BR>In patients who underwent retropubic prostatectomy, the concentrations of CPZ in the right and left lobes reached maximum values of 33.3 and 30.5 μg/g, respectively, at 8.6 min after administration. In the surgical capsule, the maximum concentration was 34.3 μg/g at 10.3 min. In patients who underwent transurethral resection, the concentration attained a maximum value of 39.8 μg/g at 2.3 min after administration. In all three patient groups, the concentration of CPZ in the prostate declined in parallel with that in serum. According to our findings concerning its bacterial inhibitory capacity and its penetration into prostate, CPZ may be effective against the bacteria that cause prostatitis and/or are detected in urine after operation for benign prostatic hyperplasia.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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