FUNDAMENTAL AND CLINICAL STUDIES ON BAY o 9867 (CIPROFLOXACIN)
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The fundamental and clinical studies on BAY o 9867 (Ciprofloxacin), a new synthesized quinoline carboxylic acid derivative were performed and the following results were obtained. All the clinical isolates of <I>S. aureus</I> (39 strains), <I>E. coli</I> (36 strains), <I>K. pneumoniae</I> (23 strains), <I>P.mirabilis</I> (28 strains), <I>P. vulgaris</I> (12 strains), <I>P.aeruginosa</I> (40 strains) were inhibited by BAY o 9867 at 3.13μg/ml or lower concentration. The peak MICs were 0.39 μg/ml against <I>S. aureus</I>, ≤0.025μg/ml against <I>E. coli</I>, 0.1μg/m l against <I>K. pneumoniae</I> and <I>P. mirabilis</I>, 0.05μg/ml against <I>P. vulgaris</I> and 0.78μg/ml against <I>P. aeruginosa</I>, respectively.<BR>BAY o 9867 was administered orally to 25 patients with acute pharyngitis (1 case), acute bronchitis (3 cases), chronic bronchitis (3 cases), infected bronchial asthma (3 cases), infected bronchiectasis (7 cases), pneumonia (7 cases), pulmonary tuberculosis (1 case) at daily doses of 400-800 mg, and 3 patients with acute simple cystitis (1 case) and chronic cystitis (2 cases) at a daily dose of 200 mg for 3-49 days.<BR>Of these patients with respiratory tract infections, 2 patients were excluded from the clinical evaluation. The clinical efficacy was "excellent" in 2, "good" in 15, "fair" in 2 and "poor" in 4, and the effective rate was 73.9%. In urinary tract infections, the clinical efficacy was "good" in 2 and "poor" in 1.<BR>As for side effect, mild epigastrial fullness and anorexia was observed in one case. No other side effect or abnormal change in laboratory examination was observed.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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