AZTHREONAM (SQ 26, 776): FUNDAMENTAL AND CLINICAL EVALUATION IN OBSTETRICS AND GYNECOLOGY
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MICs of Azthreonam were O.1μgml or less against 25 strains of <I>E. coli</I>, 20 strains of <I>K. pneumoniae</I> and 12 strains of <I>P. mirabilis</I>. Also Azthreonam demonstrated antibacterial activities against 12 strains of <I>P. aeruginosa</I>.<BR>Azthreonam provided a good transplacental passage and a good distribution into the female genital organs. Transmigration of Azthreonam into the umbilical serum was high, and that into amniotic fluid inclined to be increased up to 9 hours after the intravenous administration of Azthreonam at 1.0g.<BR>Azthreonam was effective in all 19 patients with intrauterine infection, infections of the uterine adnexa gonorrhea, and urinary tract infection when Azthreonam was administered by intravenous injection or drip injection at a daily dose of 2.0g.<BR>No abnormality observed by administration of Azthreonam in hepatic functions (GOT, GPT, Al-P) and renal function (BUN, urinary protein and others).
- 公益社団法人 日本化学療法学会の論文
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