CLINICAL EFFICACY OF AC-1370 IN TREATING COMPLICATED URINARY TRACT INFECTION
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We administered a lately developed cephem antibiotic, AC-1370, to 25 patients with complicated urinary tract infection and studied its clinical efficacy in 12 of them (6 with chronic pyelonephritis and the other 6 with chronic cystitis); and the following were found:<BR>1. Overall clinical efficacy<BR>The efficacy of the treatment was evaluated as excellent in 2, good in 8, and poor in 2 out of the 12 patients, with the effectiveness rate of 83.3%.<BR>2. Efficacy by disease classification<BR>A response rate of 100% was achieved in the patients of groups 1, 3 and 6; 75% in those of group 4, and 0% in those of group 5.<BR>3. Bacteriological response<BR>Out of 15 isolates from the urine, including 4 strains of <I>E. coli</I>, 14 were eradicated with the exception of 1 strain of <I>S. marceseens</I>.<BR>4. Side effects<BR>Out of the 25 patients treated with AC-1370, 2 complained of nausea. The drug was withdrawn from one of the 2, while the complaint disappeared from the other on switching the modality to intravenous drip. GOT, GPT and Al-P rose in another patient, but restored normal after withdrawal of the drug.
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公益社団法人 日本化学療法学会 | 論文
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