CLINICAL EVALUATION OF SULBACTAM/CEFOPERAZONE
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概要
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The MIC of cefoperazone alone (CPZ) and that of its combination with sulbactam (SBT/CPZ) were compared against clinical isolates of <I>E. coli, K. pneumoniae, E. cloacae, E. aerogenes, C. freundii, S. marcescens, and P. aeruginosa</I>. At an inoculum of 10<SUP>6</SUP> CFU/ml, SBT/CPZ showed superior MICs against all CPZ resistant organism of the clinical isolates. Clinical evaluation of SBT/CPZ was performed in 5 cases of pneumonia, 2 of bronchopneumonia complicated infection of old pulmonary tuberculosis, 2 of acute cholesystitis, 1 of biliary infection after cholesystectomy, and 1 of septicemia, in totally 12 cases. The dose of 1 or 2g b. i. d. was administered intravenously by the direct infusion or by the drip infusion for 4 to 16 days. Clinical efficacy was observed in 11 cases out of 12 cases: excellent in 3 cases, good in 8 cases and fair in one case. Organisms such as <I>S. pneumoniae, H. influenzae, K. pneumoniae, S. aureus, E. coli and E. aerogenes</I> were identified in 6 cases; all of the organisms were not detected after the administration of SBT/CPZ. Transient increases in Al-P, GOT and GPT were found in 2 cases but none of the subjective or objective side effects (rash, diarrhea etc.) were observed.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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