FUNDAMENTAL STUDY AND CLINICAL RESULTS OF ATAT-2266 IN THE OBSTETRIC AND GYNECOLOGICAL FIELD
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概要
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ATAT-2266, a new synthetic antimicrobial agent, was clinically used for the treatment of obstetric and gynecological infections. Antibacterial activity tests were performed using <I>E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa and S. aureus</I>, which were isolated from the genitalia, urinary tract or pyogenic foci. It was found that ATAT-2266 was more active than PPA. The peak MIC was 0.2μg/ml against <I>E. coli</I> and <I>K. pneumoniae</I>, 0.39μg/ml against p. mirabilis, 1.56μg/ml against <I>P. aeruginosa</I>, and 1.56μg/ml against <I>S. aureus</I>.<BR>Clinically, this drug was used in 20 cases of genital or urinary tract infections, and it was found good in all cases. The breakdown of predominant cases was as follows 3 cases of intrapelvic infections from which no organisms could be detected, 6 cases of absecess of the external genitalia from which aerobic gram-positive cocci and anaerobes were isolated, and 7 cases of cystitis caused by <I>E. coli</I>. No side effects of note were found.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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