:SUSCEPTIBILITY TO 21 ANTIBIOTICS EXCEPT BETA-LACTAM ANTIBIOTICS AND, THE PREVALENCE AND THE TREATMENT OF MULTIPLY RESISTANT STRAINS AGAINST ANTIBIOTICS CONTAINING BETA-LACTAM ANTIBIOTICS

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• We examined the susceptibility to 43 antibiotics of 343 pathogenic strains of <I>Staphylococcus aurcus</I> lately in Japan. The susceptibility to 22 beta-lactam antibiotics was already reported, so in this paper, remaining 21 antibiotics are studied with special regard to the prevalence and treatment of multiply resistant strains.<BR>The rate of resistant strains against streptomycin, kanamycin, gentamicin, amikacin, habekacin and fradiomycin were 89%, 45%, 37%, 32%, 9% and 32%, respectively, so resistant strains against aminoglycosides except habekacin increased markedly. Resistant strains against macrolides had not increased for several years and resistant strains against doxycycline decreased.<BR>Almost of all strains containing multiply resistant strains were susceptible against rifampicin, minocycline, vancomycin, sulfamethoxazole-trimethoprim and fusidic acid. However a lot of multiply resistant strains were resistant against both aminoglycosides and beta-lactam antibiotics except clozacillin, dicloxacillin and flucloxacillin.<BR>Because the overbreak of multiply resistant <I>Staphylococcus</I> aureus infection may occur from now in Japan as in U. S. A., it is very important to observe and to prevent the spread of the multiply resistant strains. We recommend that the infections due to multiply resistant strains are treated by cephaloridine, rifampicin, minocycline, vancomycin, sulfamethoxazole-trimethoprim, fusidic acid and isoxazolyl penicillins except oxacillin.

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公益社団法人 日本化学療法学会 | 論文

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