BRL14151KおよびBRL25000の生殖試験-3-ラットにおける妊娠前および妊娠初期投与試験 (BRL25000(Clavulanic acid-Amoxicillin))
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Fertility tests on BRL14151K and BRL25000 were carried out in CRJ: SD rats. BRL14151K (10, 50 and 400 mg/kg) and BRL25000 (30, 150 and 1, 200 mg/kg) were given orally to male rats for 63 days and to female rats for 14 days. Males and females treated at the same dose levels were pairedand housed together to observe mating and fertility. In females dosing was continued up to Day 7 of pregnancy to study drug effects on implantation, fetal death and development. For both compounds, temporary salivation, inhibition of weight gain, increase in water intake and increase in liver weightwere noted in high-dose groups. There were no treatment related effects on mating and pregnancyindices or spermatogenesis, oogenesis, insemination ovulation, implantation, and fetal survival, anomalies (viscera and skeleton), growth and sex ratio.
- 公益社団法人 日本化学療法学会の論文
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