Cefpiramide(SM-1652)の口腔組織移行に関する実験的・臨床的検討 (Cefpiramide(CPM,SM-1652))

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Experimental and clinical study on cefpiramide (CPM, SM-1652) were carried out in the field of oral surgery and the following results were obtained.<BR>In experimental study, 100mg/kg of cefpiramide was administered by intravenous injection in SD strain rats. The concentrations in plasma and oral tissues were measured by the means of agar-well method. The concentrations of cefpiramide in oral tissues were the highest in gingiva and followed by in tongue, salivary glands and bones in order. The concentrations after administration of cefpiramide in plasma and oral tissues were similar to cefazolin and were superior to cefoperazone.<BR>In clinical study, 13 patients with oral disease were given a dose of 1, 000 mg of cefpiramide by intravenous injection before operation. The concentration of cefpiramide in plasma and various oral tissues obtained at surgery were measured by the same method as experimental study. Plasma level of cefpiramide decreased very slowly and the distribution in oral tissues were similar to the results of experimental study. Transference of cefpiramide to inflammatory tissues was not inferior to those of normal tissues.<BR>The results indicated the usefulness of cefpiramide in the treatment of infections in the field of oral surgery.
公益社団法人日本化学療法学会の論文