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Cefoxitin, cefmetazole, cefazolin and cephaloridine antagonized the <I>in vitro</I> antibacterial activity of third generation cephem antibiotics against most of bacteria possessing inducible cephalosporinase, such as <I>Serratia, Enterobacter, Citrobacter</I>, Indole positive <I>Proteus</I> spp and <I>Pseudomonas aeruginosa</I>. The extent of antagonism varied among cephem antibiotics tested, and the ability of cefoxitin and cefmetazole to antagonize was more potent than those of cefazolin and cephaloridine. No antagonism with cefoxitin was found in the mutant strains of <I>E. cloacae</I> possessing constitutive β-lactamase. Cefoxitin-induced antagonism in strains of <I>E. cloacae</I> was inhibited by a carbapenem derivative, the β-lactamase inhibitor.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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