新しく開発されたセファマイシン系抗生物質T-1982に関する細菌学的評価 (T-1982(Cefbuperazone)<特集>)

概要

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The bacteriological evaluation of T-1982, a new cephamycin antibiotic, was studied in comparison with that of cefmetazole and cefotetan. The following results were obtained. T-1982 showed a broad antibacterial spectrum against gram-positive and gram-negative bacteria as well as cefmetazole and cefotetan, and its antibacterial activity was almost the same as cefotetan in the sensitivity distribution to various clinical isolates. Moreover, T-1982 was active against Bacteroidxs fragilis, but was not active against Pseudonumas aeruginosa. T-1982 showed a dose-response bactericidal activity against Escherichia coli, Klebsiella przeumoniae and Serratia marcescens. The correlation between MICs and MLCs of T-1982 against Escherichia coli and Serratia marcescens was similar to that of cefmetazole and cefotetan. Therapeutic effect of T-1982 on experimental infection in mice with Escherichia coli, Klebsiella pneumoniae and Serratia marcescens was somewhat superior to that of cefotetan, but inferior to that of cefmetazole on infection with Proteus morganii. The morphological change in Escherichia coil K-12 was observed by a phase contrast microscope. At concentrations of 0.05 and 0.5μg/ml, T-1982 made the bacteria elongated. A study on the binding of T-1982 to the penicilin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa E-2 revealed that T-1982 had the highest affinity for PBP 3.
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