BRL25000(Clavulanic acid-Amoxicillin)の実験的マウス皮下混合感染症に対する治療効果およびマウス盲腸内細菌叢への影響 (BRL25000(Clavulanic acid-Amoxicillin)<特集>)
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The <I>in vivo</I> antibacterial activity of BRL25000 was investigated against mouse experimental mixed infection coused by β-lactamase producing strain of <I>B. fragilis</I> and β-lactamase none producing strain of <I>E. coli</I>.<BR>The influence of treatment on mouse cecal microflora was studied following treatment with either 2mg/kg of BRL25000 or amoxicillin for 7 days.<BR>The following results were obtained.<BR>1. BRL25000 produced a more potent therapeutic effect than amoxicillin and cefazolin in the mouse experimental infection study.<BR>2. Following the administration of amoxicillin, strains of <I>C. clifficile</I> were detected in numbers in excess of 10<SUP>5</SUP>cfu/g of mouse cecal contents, whereas very small number were isolated following prophylactic treatment with BRL25000.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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